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Prophylactic Clotrimazole Treatment to Prevent Mycoses Contamination of the Newborn
Author(s) -
RuizVelasco Victor,
RosasArceo Jaime
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1978.tb00398.x
Subject(s) - clotrimazole , medicine , anus , pregnancy , vagina , obstetrics , surgery , dermatology , antifungal , genetics , biology
One hundred gravid women between 32 and 36 weeks of pregnancy who had vaginal moniliasis were selected to evaluate clotrimazole therapy as a means of preventing fungal contamination of the newborn. Fifty of these women received clotrimazole therapy in the form of vaginal tablets and cream for the duration of their pregnancies. The remaining 50 women were given placebos and served as the control group. Results of cultures taken at delivery from the mothers' vaginas revealed that 88% of the treated group were negative as compared to 42% of the control group. Cultures taken from the newborn's back at delivery and those taken from the mouth, anus and inguinal folds three days later clearly demonstrated the effectiveness of clotrimazole therapy. We conclude that clotrimazole is an effective antimycotic drug when used to control vaginal candidiasis in pregnant women and to prevent fungal contamination of the fetus as it comes in contact with the infected area at delivery.