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Sex Steroids and Thyroid Function Tests: The Role of Estrogen and Progestogen
Author(s) -
Miyamoto Junhaku
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1978.tb00386.x
Subject(s) - progestogen , estrogen , medicine , endocrinology , triiodothyronine , hormone , thyroid function , thyroid function tests , thyroid , sex hormone binding globulin , globulin , androgen
Thyroid functions were evaluated in 102 women by comparing changes during administration of estrogen, progestogen and a combination of estrogen and progestogen. Total thyroxine (T 4 ) concentrations were significantly elevated in women receiving estrogen and estrogen‐progestogen. Parallel increases of total triiodothyronine (T 3 ) were observed in women in the estrogen groups, except for those receiving conjugated estrogen. The use of estrogens resulted in decreased T 3 resin uptake values and increased thyroxine‐binding globulin (TBG) capacity levels, thus showing the negative correlation between these determinations. In the ethinyl estradiol and mestranol‐norethindrone groups, the free thyroxine index (FTI), calculated by dividing the total T 4 by the total TBG, fell within normal ranges. No significant changes of total T 4 , total T 3 , T 3 resin uptake, TBG capacity and FTI values were noted in women taking progestogen. Serum levels of thyroid‐stimulating hormone were normal in women taking estrogen and/or progestogen.