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Rapid Assays of Urinary Estriol in Pregnant Women
Author(s) -
Miyakawa Isao,
Nakayama Michio,
Miyazaki Kouji,
Maeyama Masao,
Mori Norimasa
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1977.tb00695.x
Subject(s) - medicine , estriol , urine , urinary system , pregnancy , gynecology , obstetrics , urology , estrogen , biology , genetics
Two devices designed for rapid assay of urinary estriol, the E 3 KIT and the E 3 HAIR KIT, were evaluated using urine samples taken from pregnant women. Additionally, the clinical application of these devices in pregnancy management was examined. Correlations were high between an established method and the E 3 KIT method (r=0.819, p<0.001) and between the E 3 HAIR KIT method and the E 3 KIT method (r=0.936, p<0.01). E 3 HAIR KIT assays showing E 3 values of less than 20 μg/ml (positive at 100‐fold dilution of the urine) after the 36th week of pregnancy suggested fetoplacental dysfunction and indicated that more detailed tests were required. The E 3 KIT, which provided rapid quantitative assay of urinary estriol, was capable of measuring 10 samples in approximately 3 hours. The E 3 HAIR KIT provided semiquantitative assays of 10 samples in 2 hours. The speed, simplicity, and accuracy of the E 3 HAIR KIT indicates its high clinical value as a prospective large‐scale screening method for fetoplacental function.