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Repeated Extra‐amniotic Administration of Prostaglandin F 2α for Midtrimester Abortion
Author(s) -
Ragab M. Ismail,
Edelman David A.
Publication year - 1976
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1976.tb00623.x
Subject(s) - medicine , abortion , vomiting , prostaglandin , obstetrics , amniotic fluid , diarrhea , gestation , pregnancy , fetus , incomplete abortion , anesthesia , misoprostol , genetics , biology
ABSTRACT Midtrimester abortion was induced in 94 of 100 patients at 16 to 24 weeks' gestation by the extra‐amniotic administration of 1 170 μg of prostaglandin F 2α (PGF 2α ) every 10 minutes. The number of prostaglandin doses varied from 16 to 24 depending on the patient's response to the prostaglandin. The median abortion time was 10.0 hours, and 82.0% of the patients aborted within 24 hours. Overall, 68.0% of the patients failed to expel the placenta within one hour of abortion of the fetus. Vomiting and diarrhea occurred among 42.0 and 17.0% of the patients, respectively. Compared with the intra‐amniotic administration of a single 50 mg dose of PGF 2α , the extra‐amniotic procedure was associated with similar side effect rates, a higher rate of incomplete abortion, and a significantly shorter abortion time.