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Midtrimester Abortion
Author(s) -
Ragab M. Ismail,
Edelman David A.
Publication year - 1976
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1976.tb00072.x
Subject(s) - medicine , abortion , hypertonic saline , saline , obstetrics , prostaglandin , gynecology , anesthesia , pregnancy , genetics , biology
Ragab, M. I. and Edelman, D. A. (Ain Shams University, Cairo, Egypt and International Fertility Research Program, Research Triangle Park, North Carolina, USA). Midtrimester abortion. A comparison of intraamniotic prostaglandin F 2α and hypertonic saline . Int J Gynaecol Obstet 14 : 393–396, 1976. The safety and effectiveness of two intraamniotic prostaglandin F 2α (PGF 2α ) dose schedules (a single 50 mg dose and a repeated 25 mg dose) and intraamniotic hypertonic saline were evaluated in a study where each abortion procedure was randomly assigned to 50 patients. All patients were at 16 to 20 weeks’ gestation. Rates of gastrointestinal and other side effects were generally higher for the 50 mg PGF 2α dose schedule than for the other two procedures. Complications were infrequent with all three study procedures. The repeated 25 mg PGF 2α dose schedule resulted in higher 24‐hour (68.0%) and 48‐hour (98.0%) cumulative abortion rates than the 50 mg PGF 2α dose schedule (54.0%, 92.0%) or saline (34.7%, 91.8%). Rates of spontaneous placental expulsion were highest for the repeated 25 mg PGF 2α dose (74.0%) and lowest for the 50 mg PGF 2α dose schedule (40.0%).