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The Treatment of Oligospermia with Various Dosage Regimes of Gonadotropins
Author(s) -
Diejomaoh Michael F. E.,
Bichacho Shlomo,
Epstein Jeanne A.,
Sobrero Acquiles J.
Publication year - 1975
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1975.tb00060.x
Subject(s) - medicine , oligospermia , pregnancy rate , pregnancy , semen quality , fertility , gynecology , semen , obstetrics , infertility , andrology , male infertility , population , biology , genetics , environmental health
Diejomaoh, M. F. E., Bichacho, Sh., Epstein, J. A. and Sobrero, A. J. (All formerly of the Margaret Sanger Research Bureau, 17 West 16th Street, New York, NY, USA). The treatment of oligospermia with various dosage regimes of gonadotropins . Int J Gynaecol Obstet 13 : 241–248, 1975. The report of 96 normogonadotropic oligospermic infertile males, 50 of whom were treated with high HCG doses of 10000 units twice weekly for 10 weeks, 24 of whom were treated with moderate HCG dose of 5000 units twice weekly for 10 weeks and 22 of whom received combination therapy of HCG 5000 units and PMS 750 units twice weekly for 10 weeks is here presented. In the first group, seven patients (14%) had improvement in seminal quality with a single subsequent pregnancy whereas in the latter two groups, 11 patients (23.9%) had improvement in seminal quality with six subsequent pregnancies. The overall pregnancy rate in the series was 23.95%; the overall pregnancy rates for the two groups of patients were virtually equal, although most of the pregnancies in the high HCG dosage schedule occurred in the absence of seminal improvement. Varicocelectomy did not improve the pregnancy rate in this series. Female fertility problems did not hinder the occurrence of pregnancy in this series as such female fertility problems were usually corrected. No correlation was found between testicular pathology and improvement in semen quality.