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Tramadol‐Warfarin Interaction
Author(s) -
Sabbe Jonell R.,
Sims Pamela J.,
Sims Marion H.
Publication year - 1998
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1998.tb03914.x
Subject(s) - tramadol , warfarin , medicine , prothrombin time , anesthesia , coagulation , surgery , atrial fibrillation , analgesic
A 61‐year‐old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily stopping warfarin. The mechanism for this interaction is unknown. Practitioners should be aware of the possibility of such a interaction and exercise caution when tramadol is prescribed for a patient receiving warfarin.