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Phenytoin Toxicity in an Older Patient with Slow Metabolism and Atypical Presentation
Author(s) -
Pitner Janet K.,
Long Lesle D.,
Meyer Reneé P.,
Pennypacker Leslye C.
Publication year - 1998
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1998.tb03842.x
Subject(s) - phenytoin , toxicity , haloperidol , medicine , anticonvulsant , altered mental status , pharmacology , anesthesia , pediatrics , epilepsy , psychiatry , dopamine
Phenytoin toxicity occurred in an older man who received a dosage of 300 mg/day. The patient developed high serum phenytoin concentrations from this common adult dosage, with symptoms of functional decline and altered mental status. These behaviors were perceived as sun‐downing and were treated with haloperidol. A long hospitalization was required.