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The Pharmacokinetics of Intravenous Estradiol—A Preliminary Study
Author(s) -
White C. Michael,
FerraroBorgida Melissa J.,
Fossati Andrea T.,
McGill Carol C.,
Ahlberg Alan W.,
Feng Yue Jin,
Heller Gary V,
Chow Moses S. S.
Publication year - 1998
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1998.tb03157.x
Subject(s) - pharmacokinetics , medicine , intravenous bolus , dose , dosing , bolus (digestion) , volume of distribution , half life , pharmacology , anesthesia
Estradiol USP was extemporaneously compounded for intravenous administration. Eight postmenopausal women were randomized to receive one of four estradiol dosages. Serum estradiol concentrations were determined at frequent intervals after single bolus dosing. The concentration‐time profile was stripped and fit, and pharmacokinetic values were generated. Approximate dosage proportionality was seen with area under the curve, the terminal half‐life was 27.45 ± 5.65 minutes, and volume of distribution was very low (0.082 ± 0.015 L/kg). Estradiol was well tolerated by all study participants.