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Failure of Once‐Daily Vancomycin for Staphylococcal Endocarditis
Author(s) -
Marik Paul E.
Publication year - 1998
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1998.tb03130.x
Subject(s) - medicine , vancomycin , dosing , endocarditis , antibiotics , staphylococcus aureus , staphylococcal infections , regimen , intensive care medicine , surgery , microbiology and biotechnology , bacteria , biology , genetics
With the emergence of staphylococci as important hospital pathogens, administration of vancomycin has increased dramatically. Economic and other factors have led to the development of once‐daily dosing protocols to simplify and standardize the administration of antibiotics. A patient with Staphylococcus aureus prosthetic valve endocarditis and normal renal function failed therapy with vancomycin once/day. The infection was cured when the regimen was changed to the conventional 12‐hour dosing interval.