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Azathioprine‐Induced Multisystem Organ Failure and Cardiogenic Shock
Author(s) -
Brown Glen,
Boldt Camilla,
Webb John G.,
Halperin Lawrence
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03761.x
Subject(s) - azathioprine , cardiogenic shock , medicine , organ dysfunction , organ system , intensive care medicine , complication , cardiac dysfunction , cardiology , heart failure , disease , sepsis , myocardial infarction
Azathioprine is administered to treat increasing numbers of disorders over a wide range of organ systems. The potential for the drug to cause widespread organ dysfunction is not fully appreciated. In fact, azathioprine can cause multisystem organ dysfunction involving the kidneys, liver, and cardiovascular system. The discovery of global cardiac dysfunction as one component of this complication may indicate a mechanism of hypotension. Clinicians must be aware of the potential for azathioprine to cause such toxicities to facilitate appropriate patient management.