Premium
A Review of the Effects of Plasmapheresis on Drug Clearance
Author(s) -
KalePradhan Pramodini B.,
Woo Michael H.
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03744.x
Subject(s) - plasmapheresis , drug , pharmacokinetics , metabolic clearance rate , pharmacology , medicine , intensive care medicine , immunology , antibody
Plasmapheresis (PP) is being increasingly performed to treat a number of infectious, immunologic, metabolic, and inherited illnesses. In this procedure, plasma and cellular components of blood are separated, and all solutes in plasma, including drugs, can be removed. The effects of PP on the pharmacokinetics of drugs administered therapeutically and taken in overdose are evolving. As the procedure becomes more widely performed, it is important that these effects be understood.