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T Lymphocyte β 2 ‐Adrenergic Receptor Function and Density after Acute Myocardial Infarction
Author(s) -
McCoy Randall A.,
Clifton G. Dennis,
Booth David C.,
Bartels Laura A.,
Chandler Mary H.H.
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03720.x
Subject(s) - myocardial infarction , medicine , lymphocyte , cardiology , endocrinology , cyclic adenosine monophosphate , stimulation , receptor , adrenergic receptor , coronary artery disease , adrenergic
The T lymphocyte β 2 ‐adrenergic receptor (β 2 AR) density and function were compared in 15 patients suffering acute myocardial infarction and 10 patients with stable coronary artery disease (CAD). Density was determined using radioligand binding with 125 IPIN, and function by in vitro cyclic adenosine 3′,5′‐monophosphate (cAMP) production. In patients suffering acute myocardial infarction, T lymphocyte β 2 AR density (823.8 ± 480 sites/cell) was slightly but not significantly different from that in patients with stable CAD (629 ± 301 sites/cell). There was no difference in T lymphocyte cAMP production at baseline (1.11 ± 0.70 vs 1.04 ± 0.49 pM/10 6 cells) or after isoproterenol stimulation (2.53 ± 1.63 vs 2.62 ± 2.05 pM/10 6 cells), respectively. Further study is necessary to determine if β 2 AR numbers on T lymphocytes are significantly increased after acute myocardial infarction.