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Serum Sickness Associated with 6‐Mercaptopurine in a Patient with Crohn's Disease
Author(s) -
Andersen Judith M.,
Tiede James J.
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03692.x
Subject(s) - medicine , mercaptopurine , rash , malaise , disease , vasculitis , serum sickness , dermatology , crohn's disease , immunology , antibody
A 43‐year‐old man with a 19‐year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6‐mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, proteinuria, fever, rash, and malaise. To our knowledge, this adverse drug reaction has not been described in association with 6‐mercaptopurine.