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Delayed Hypersensitivity Reaction to Vancomycin
Author(s) -
Marik Paul E.,
Ferris Nan
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03104.x
Subject(s) - medicine , vancomycin , discontinuation , methylprednisolone , staphylococcus aureus , eosinophilia , hypersensitivity reaction , erythema , dermatology , biology , bacteria , genetics
The use of vancomycin has increased dramatically in recent years with the emergence of methicillin‐resistant Staphylococcus aureus and coagulase‐negative staphylococci as important hospital pathogens. A patient receiving vancomycin 1.75 g intravenously as a single daily dose developed a syndrome characterized by high fever, erythema multiforme, eosinophilia, and presumed interstitial nephritis. This delayed hypersensitivity reaction resolved with discontinuation of the drug and treatment with methylprednisolone.