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Prolonged Hypoglycemic Crisis Associated with Glyburide
Author(s) -
Sills Michael N.,
Ogu Chris C.,
Maxa Jan
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03103.x
Subject(s) - medicine , hypoglycemia , diabetes mellitus , complication , hepatic dysfunction , intensive care medicine , anesthesia , pediatrics , endocrinology
An elderly patient taking glyburide 5 mg/day for noninsulin‐dependent diabetes mellitus was hospitalized because of severe hypoglycemia. Laboratory results indicated both renal and hepatic abnormalities were present at the time of admission. Despite infusion of 10% dextrose and supplemental boluses of 50% dextrose, the hypoglycemic crisis persisted for 3 days. After it resolved, the patient's diabetes was controlled by diet alone. The patient's age and the presence of hepatic and/or renal impairment must be taken in account in prescribing glyburide. Recognizing patients who may require dosage changes, and educating them on the signs and symptoms of hypoglycemia, may help prevent hospitalizations resulting from this complication associated with glyburide.