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Recurrent Clostridium difficile Diarrhea Associated with Mitoxantrone and Etoposide: A Case Report and Review
Author(s) -
Jarvis Blair,
Shevchuk Yvonne M.
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03072.x
Subject(s) - diarrhea , medicine , mitoxantrone , clostridium difficile , antibiotics , etoposide , gastroenterology , c difficile , antibiotic associated diarrhea , chemotherapy , microbiology and biotechnology , biology
Clostridium difficile colitis most commonly occurs in association with antibiotic administration and infrequently with antineoplastic agents. Our patient experienced recurrent C. difficile diarrhea associated with mitoxantrone and etoposide. He received antibiotics during the 6 months, but each episode of diarrhea was preceded by at least a 6‐week antibiotic‐free period. In addition, antineoplastic therapy preceded each episode by 8 or 9 days. Clinicians should be aware that antineoplastic drugs may precipitate overgrowth of C. difficile in the bowel.