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Sertraline‐Associated Syndrome of Inappropriate Antidiuretic Hormone: Case Report and Review of the Literature
Author(s) -
Bradley Mary E.,
Foote Edward F.,
Lee Edwin N.,
Merkle Larry
Publication year - 1996
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1996.tb03652.x
Subject(s) - sertraline , antidiuretic , medicine , hyponatremia , depression (economics) , hypertonic saline , vasopressin , endocrinology , pediatrics , antidepressant , hippocampus , economics , macroeconomics
Selective serotonin reuptake inhibitors have gained widespread use in the treatment of depression. A 78‐year‐old woman became hyponatremic 3 days after being treated with sertraline and was subsequently diagnosed with the syndrome of inappropriate antidiuretic hormone (SIADH). She became symptomatic, but experienced rapid resolution of the laboratory and clinical abnormalities associated with SIADH on discontinuing sertraline and receiving fluid restriction, hypertonic saline, and demeclocycline. Several mechanisms may relate SIADH and vasopressin release to serotonin.