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Failure of Prostatitis Treatment Secondary to Probable Ciprofloxacin‐Sucralfate Drug Interaction
Author(s) -
Spivey J. Michael,
Cummings Doyle M.,
Pierson Noah R.
Publication year - 1996
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1996.tb02952.x
Subject(s) - sucralfate , ciprofloxacin , antibiotics , bioavailability , drug , medicine , concomitant , pharmacology , drug interaction , prostatitis , trichuris trichiura , ferrous , chemistry , immunology , prostate , cancer , biochemistry , organic chemistry , helminths , ascaris lumbricoides
Metal cations such as aluminum, magnesium, ferrous sulfate, and zinc are thought to form chelation complexes with fluoroquinolone antibiotics and prevent the drugs from being absorbed. Sucralfate, which has a high aluminum content, reduces the bioavailability of ciprofloxacin to approximately 4%. The concomitant administration of ciprofloxacin and sucralfate resulted in treatment failure for a patient with prostatitis and a subsequent 5‐day hospitalization. Fluoroquinolone antibiotics should be administered at least 2 hours before agents containing metal cations to allow for their absorption. In addition, sucralfate should not be administered less than 6 hours before fluoroquinolone antibiotic administration.