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Novel versus Conventional Antipsychotic Drugs
Author(s) -
Love Raymond C.
Publication year - 1996
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1996.tb02929.x
Subject(s) - antipsychotic , akathisia , extrapyramidal symptoms , pharmacology , schizophrenia (object oriented programming) , dopamine receptor d2 , medicine , 5 ht receptor , serotonin , adverse effect , dopamine , receptor , psychiatry
Novel antipsychotic agents differ from conventional ones in several key characteristics, including effectiveness, adverse reactions, and receptor‐binding profile. Most of the newer agents have an affinity for the serotonin 5HT 2 receptor that is at least f 0 times greater than that for the dopamine D 2 receptor. This increased affinity for the serotonin receptor may be responsible for another distinguishing characteristic of novel antipsychotic agents—decreased frequency of extrapyramidal side effects. These side effects, which include pseudoparkinsonism, acute dystonias, and akathisia, frequently are the reason for noncompliance with conventional drug therapy. The newer drugs are often effective in patients resistant to treatment with conventional agents. They also appear to reduce the negative symptoms of schizophrenia in many patients.