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Computer‐Assisted Continuous Infusion for the Delivery of Target‐Controlled Infusions of Propofol During Outpatient Surgery
Author(s) -
Arndt George A.,
Reiss William G.,
Bathke Kris A.,
Springman Scott R.,
Kenny Gavin
Publication year - 1995
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1995.tb04390.x
Subject(s) - propofol , medicine , anesthesia , infusion pump , syringe driver , ambulatory , continuous infusion , hemodynamics , target controlled infusion , syringe , surgery , remifentanil , psychiatry
Propofol was administered intravenously using a first‐order, three‐compartment, computer‐controlled infusion pump (CCIP) based on the Ohmeda 9000 syringe pump. The CCIP system produced a target‐controlled infusion (TCI) based on the estimated blood concentration (EBC). Twenty‐five patients undergoing ambulatory surgery completed the study. The induction EBC was 4.72 ± 0.28 μg/ml, and was achieved rapidly with minimal hemodynamic changes. The emergence EBC was 1.55 ± 0.21 μg/ml, and the discharge EBC was 1.06 ± 0.22 μg/ml. The EBC, together with clinical signs, allowed for predictable inductance and emergence from anesthesia using propofol.