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Does Ranitidine Affect Blood Alcohol Concentrations?
Author(s) -
Pipkin Graham A.,
Mills Jane G.,
Wood John R.
Publication year - 1994
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1994.tb02821.x
Subject(s) - ranitidine , alcohol , ethanol , blood alcohol , chemistry , stomach , pharmacokinetics , pharmacology , medicine , anesthesia , biochemistry , poison control , injury prevention , emergency medicine
No interaction occurs between ranitidine and alcohol when alcohol 0.3 g/kg or more is taken by either fed or fasted subjects. Ranitidine is associated with small increases (2–4 mg/dl) in blood alcohol concentrations in subjects given alcohol 0.15 g/kg under specific experimental conditions. Mean peak blood alcohol concentrations nevertheless remain low (<20 mg/dl) after that amount, which is equivalent to about 3 oz of wine or 1 oz of 80‐proof liquor. Such changes also occur when alcohol is ingested after different types of foods, and are smaller than the increases when it is drunk on an empty compared with a full stomach. The pharmacokinetic effect seen with ranitidine is without apparent clinical or social significance.