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Complete Heart Block and Torsade de Pointes Associated With Thioridazine Poisoning
Author(s) -
Hulisz Darrell T.,
Dasa Sridevi L.,
Black Lisa D.,
Heiselman Darell E.
Publication year - 1994
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1994.tb02816.x
Subject(s) - thioridazine , medicine , atrioventricular block , anesthesia , heart block , long qt syndrome , acetaminophen , adverse effect , block (permutation group theory) , torsades de pointes , codeine , electrocardiography , qt interval , cardiology , chlorpromazine , geometry , mathematics , morphine
A 72‐year‐old woman attempted suicide with thioridazine 3000 mg and 60 tablets of acetaminophen 325 mg plus codeine 30 mg. She was semicomatose and had persistent third‐degree atrioventricular block, progressive hypotension, and an episode of torsade de pointes. Heart block, arrhythmias, and hypotension resolved within 48 hours, and the patient recovered without adverse sequelae.