Premium
Symptomatology, Pulmonary Function and Response, and T Lymphocyte β2‐Receptors During Smoking Cessation in Patients With Chronic Obstructive Pulmonary Disease
Author(s) -
Leader W. Greg,
Wolf Karen M.,
Cooper Thomas M.,
Chandler Mary H.H.
Publication year - 1994
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1994.tb02803.x
Subject(s) - medicine , copd , smoking cessation , nicotine , pulmonary function testing , cotinine , terbutaline , lymphocyte , endocrinology , asthma , pathology
Study Objectives . To characterize the effect of smoking cessation and nicotine replacement on pulmonary symptomatology, baseline pulmonary function and response to terbutaline, and purified T lymphocyte β 2 ‐receptor regulation; and the relationship between T lymphocyte β 2 ‐receptor density and pulmonary function. Design . Open‐label, longitudinal, 28‐week study. Setting . A university clinical research center. Patients . Eighteen long‐term smokers with mild to moderate chronic obstructive pulmonary disease (COPD) were enrolled and seven completed the study. Interventions . Subjects stopped smoking with the aid of nicotine substitution and behavioral counseling. Pulmonary response (FEVi) to subcutaneous terbutaline and T lymphocyte β 2 ‐receptor density (B max ) and function (cAMP) were measured prior to smoking cessation (week 0), during nicotine replacement (week 8), and after nicotine cessation (week 28). Measurements and Main Results . Serum cotinine concentrations, plasma epinephrine concentrations, and day and night cough decreased significantly after smoking cessation, whereas basal cAMP concentrations increased (p<0.05). No significant change was seen in baseline FEV 1 , pulmonary response to terbutaline, or B max over the 28 weeks; however, intrasubject changes in B max between visits correlated significantly (p<0.05) with intrasubject changes in pulmonary response between visits. Conclusions . Our data indicate that smoking cessation is associated with a significant decrease in the symptomatology of COPD, and that change in T lymphocyte β 2 ‐receptor density is a good marker of change in pulmonary response to β 2 ‐agonists.