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Assessment of the Effects of Ciprofloxacin and Nalidixic Acid on Cerebral Blood Flow and Metabolism in Healthy Subjects by Positron Emission Tomography
Author(s) -
Bednarczyk Edward M.,
Adler Lee E,
Remler Bernd,
Goyer Peter,
Wiznitzer Max,
Leisure Gregory P.,
Little Dana,
Miraldi Floro
Publication year - 1994
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1994.tb02802.x
Subject(s) - positron emission tomography , cerebral blood flow , placebo , nalidixic acid , blood flow , medicine , ciprofloxacin , oxygen metabolism , anesthesia , metabolism , nuclear medicine , endocrinology , oxygen , chemistry , antibiotics , biochemistry , pathology , alternative medicine , organic chemistry
Study Objectives . The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown. Using positron emission tomography (PET), we evaluated the effects of two quinolones on brain blood flow as well as on oxygen and glucose metabolism. These determinations were done in conjunction with ophthalmologic and neuro‐ophthalmologic testing. Design . Randomized, double‐blind, placebo‐controlled, 7‐day course of ciprofloxacin 750 mg (C750) or 500 mg (C500) every 12 hours, or nalidixic acid (NA) 1 g every 6 hours. Population . Twenty‐four healthy male volunteers, six in each treatment arm. Results . Conclusions . Compared with baseline values, NA significantly reduced brain glucose uptake, whereas C500, C750, and placebo produced no detectable effect. No compound significantly altered brain blood flow or oxygen metabolism compared with baseline or other treatments. No significant effect on electroretinographic, electro‐oculographic, or other neuro‐ophthalmologic tests was observed.