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Predictors of Trough Concentrations of Oral Ciprofloxacin
Author(s) -
Paladino Joseph A.,
Forrest Alan,
Wilton John H.
Publication year - 1993
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1993.tb04315.x
Subject(s) - creatinine , renal function , trough (economics) , linear regression , medicine , body surface area , trough concentration , stepwise regression , linear relationship , ciprofloxacin , urology , gastroenterology , chemistry , mathematics , pharmacokinetics , statistics , antibiotics , biochemistry , economics , macroeconomics
Patients enrolled in a fixed‐dose clinical trial of oral ciprofloxacin had trough concentrations measured to document absorption and monitor compliance. The objective was to determine whether any demographic characteristics might be important predictors of the concentrations. Stepwise multivariate linear regression revealed no correlation between ciprofloxacin trough concentrations and serum creatinine, estimated creatinine clearance (CI cr ), weight, height, body surface area, or gender. However, age exhibited a direct linear relationship with trough concentrations (Y in μg/ml), Y = 0.020 · age −0.541 (p<0.003). We conclude that for patients with CI cr 30 ml/minute or above, age is a more important predictor of ciprofloxacin trough concentration than renal function. Dosage adjustment should not be arbitrary but should be guided by minimum inhibitory concentration, clinical response, and side effects.