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Nonsteroidal Antiinflammatory Drugs and Certain Rare, Serious Adverse Events: A Cohort Study
Author(s) -
Jick Hershel,
Derby Laura E.,
Rodríguez Luis A. García,
Jick Susan S.,
Dean Alan D.
Publication year - 1993
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1993.tb02726.x
Subject(s) - piroxicam , medicine , diclofenac , naproxen , adverse effect , cohort , nonsteroidal , population , neutropenia , methemoglobinemia , intensive care medicine , pharmacology , anesthesia , toxicity , pathology , alternative medicine , environmental health
We performed a population‐based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.