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The Effect of Isradipine on Theophylline Pharmacokinetics in Healthy Volunteers
Author(s) -
Perreault Marc M.,
Kazierad David J.,
Wilton John H.,
Izzo Joseph L.
Publication year - 1993
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1993.tb02700.x
Subject(s) - theophylline , isradipine , placebo , crossover study , pharmacokinetics , dose , volume of distribution , medicine , morning , washout , pharmacology , anesthesia , dihydropyridine , alternative medicine , pathology , calcium
The effects of isradipine 2.5 mg and 5 mg on the disposition of theophylline were investigated in a placebo‐controlled, randomized, three‐way, crossover trial. Eleven healthy, nonsmoking men each received a treatment of placebo, and isradipine 2.5 mg and 5 mg every 12 hours for 6 consecutive days. On the morning of day 6, 2 hours after the isradipine dose, theophylline (solution) 5.0 mg/kg was administered orally, and blood samples were collected over 24 hours. A 2‐week washout period separated treatment sequences. Plasma samples were analyzed for theophylline using high‐performance liquid chromatography. Using a two‐way analysis of variance, no significant changes in apparent theophylline clearance were observed between placebo, and isradipine 2.5 and 5 mg (0.815 ± 0.164, 0.870 ± 0.212, and 0.827 ± 0.164 ml/min/kg, respectively; p=0.136). Similarly, no significant change in volume of distribution was noted. These findings suggest that isradipine at recommended dosages does not impair theophylline metabolism.