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Sinus Arrest Associated With Continuous‐Infusion Cimetidine
Author(s) -
Hulisz Darrell T.,
Welko Jeffrey R.,
Heiselman Darell E.
Publication year - 1993
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1993.tb02691.x
Subject(s) - cimetidine , medicine , continuous infusion , anesthesia , ranitidine , sinus (botany) , botany , biology , genus
The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40‐year‐old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous‐infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous‐infusion cimetidine.