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Growth Factors in Nutritional Support
Author(s) -
Hatton Jimmi,
Luer Mark S.,
Rapp Robert P.
Publication year - 1993
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1993.tb02686.x
Subject(s) - anabolism , recombinant dna , endogeny , catabolism , human growth hormone , growth factor , mechanism (biology) , protein catabolism , endocrinology , biology , growth hormone , hormone , medicine , biochemistry , metabolism , amino acid , receptor , gene , philosophy , epistemology
Protein catabolism occurs in the severely stressed patient despite adequate protein supplementation. Supplementation of endogenous growth factors is one mechanism being evaluated to promote anabolism and improve nitrogen retention. Recombinant technology has provided a means to reproduce these endogenous growth factors. Both recombinant human growth hormone (rGH) and recombinant human insulin‐like growth factor‐1 (rhIGf‐1) are undergoing clinical trials to establish their roles in nutritional support.