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Potential Warfarin‐Ciprofloxacin Interaction in Patients Receiving Long‐Term Anticoagulation
Author(s) -
Bianco Theresa M.,
Bussey Henry I.,
Farnett Lisa E.,
Linn William D.,
Roush Maura K.,
Wong Y.W. James
Publication year - 1992
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1992.tb04485.x
Subject(s) - warfarin , ciprofloxacin , medicine , placebo , oral anticoagulant , drug interaction , quinolone , anticoagulant , randomized controlled trial , antibiotics , surgery , atrial fibrillation , pharmacokinetics , alternative medicine , pathology , microbiology and biotechnology , biology
This study prospectively evaluated the potential interaction between the oral anticoagulant warfarin and the quinolone antimicrobial agent ciprofloxacin. After a 10‐day placebo lead‐in phase, 16 patients stabilized with long‐term warfarin therapy were randomized to receive ciprofloxacin 500 mg or a matching placebo twice/day for 10 days. International normalized ratios (INRs) measured by both standard laboratory analysis and by Coumatrak (finger‐stick) methods were evaluated at 3‐ to 5‐day intervals. No patient experienced a significant increase in INR. No patient experienced a bleeding event. These data support the fact that a warfarin‐ciprofloxacin interaction does not routinely occur at this dosage and duration of ciprofloxacin therapy.