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Increase in Serum Digoxin Concentrations After Indomethacin Therapy in a Full‐Term Neonate
Author(s) -
Haig George M.,
Brookfield Ernest G.
Publication year - 1992
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1992.tb04468.x
Subject(s) - digoxin , medicine , creatinine , therapeutic index , serum concentration , heart failure , toxicity , full term , therapeutic drug monitoring , anesthesia , pharmacology , pregnancy , drug , biology , genetics
Digoxin was administered to an 18‐day‐old infant who showed evidence of cardiac failure. When a Doppler echogram revealed a patent ductus, indomethacin was administered for medical management. Therapeutic digoxin doses then resulted in toxic serum concentrations of 8.2 ng/ml. Serum creatinine rose accordingly. Although this patient did not manifest signs of digoxin toxicity, practitioners should be alerted to the potential complications of these commonly used agents.