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Captopril Ameliorates the Posturally Induced Fall in Creatinine Clearance in Patients With Chronic Glomerulonephritis
Author(s) -
Kuriyama Satoru,
Shimada Toshiki,
Hashimoto Takao,
Sakai Osamu
Publication year - 1992
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1992.tb03624.x
Subject(s) - captopril , supine position , medicine , orthostatic vital signs , creatinine , renal function , endocrinology , renal biopsy , urology , blood pressure
The clinical usefulness of an angiotensin‐converting enzyme inhibitor on the posturally induced fall in creatinine clearance (Cl cr ) was studied in patients with biopsy‐proved chronic glomerulonephritis (CGN). After a change from supine to upright position, Cl cr fell significantly in all patients. This fall was significantly ameliorated by the pretreatment with captopril (fall in Cl cr 28.8 ± 14.3% for nontreated vs 16.5 ± 11.5% for treated patients; n = 12; p<0.05). The ameliorating effect was more marked in patients with mesangial cell proliferation (MP) than those without it (fall in Cl cr 7.2 ± 6.3% for MP vs 17.1 ± 12.3% for no MP; n=6; p<0.05). The results suggest that captopril apparently had a renoprotective effect on the orthostatic acute fall in Cl cr in patients with CGN, especially those with MP.