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Hematopoiesis
Author(s) -
Smith Steven P.,
Yee Gary C.
Publication year - 1992
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1992.tb02678.x
Subject(s) - haematopoiesis , microbiology and biotechnology , biology , blood cell , stem cell , induced pluripotent stem cell , cell growth , function (biology) , platelet , immunology , genetics , gene , embryonic stem cell
Hematopoiesis begins with the pluripotent stem cell in the marrow and culminates in mature, functional red blood cells, white blood cells, and platelets in the circulation. The process consists of a complex and well‐orchestrated sequence of cell proliferation, differentiation, and maturation, that is stimulated and regulated by a host of cytokines and hormones. The various growth factors act individually and in concert at different stages of hematopoiesis and have important effects on mature cell function.