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Toxic Shock‐Like Syndrome
Author(s) -
Erstad Brian L.,
Witte Charles L.,
Talkington Deborah F.
Publication year - 1992
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1992.tb02666.x
Subject(s) - toxic shock syndrome , fasciitis , streptococcus , shock (circulatory) , medicine , exotoxin , group a , debridement (dental) , streptococcus pyogenes , disease , antibiotics , dermatology , surgery , microbiology and biotechnology , biology , toxin , staphylococcus aureus , bacteria , genetics
Invasive group A streptococcal infection has important diagnostic and therapeutic implications in patients with necrotizing fasciitis. We cared for a man with the full‐blown syndrome in whom many features of toxic shock syndrome were present, including profound hypotension and renal failure. The diagnostic similarities of toxic shock syndrome and the toxic shock‐like syndrome caused by group A Streptococcus could have led to inappropriate treatment. Successful therapy in our patient included high doses initially of broad‐spectrum antibiotics, repeated operative debridement of the lower leg (the affected limb), and ultimately, reconstructive surgery consisting primarily of split‐thickness skin grafts. The reemergence of invasive streptococcal infections may relate to changes either in virulence factors of the causative streptococcus or in exotoxins elaborated by this microorganism. A causative relationship between an exotoxin produced by group A Streptococcus and the toxic shock‐like syndrome has not yet been established.