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Prolonged Nausea and Vomiting Associated with Buprenorphine
Author(s) -
Fullerton Terence,
Timm Edward G.,
Kolski Gerald B.,
Bertino Joseph S.
Publication year - 1991
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1991.tb03604.x
Subject(s) - nausea , vomiting , buprenorphine , anesthesia , medicine , morphine , opioid , receptor
We conducted a trial to evaluate the histamine‐releasing characteristics of morphine, meperidine, and buprenorphine when administered intravenously to 20 healthy adults without pain. Substantially more nausea and vomiting occurred with buprenorphine than with the other compounds, and was more intense on ambulation. High‐affinity receptor binding may play a role in the long duration of nausea and vomiting after a single dose of this agent.