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Fatal Hepatotoxicity Induced by Hydralazine or Labetalol
Author(s) -
Stumpf Janice L.
Publication year - 1991
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1991.tb02650.x
Subject(s) - labetalol , hydralazine , medicine , discontinuation , adverse effect , pharmacology , confusion , anesthesia , intensive care medicine , blood pressure , psychology , psychoanalysis
Antihypertensive agents have been associated with adverse reactions that, if unrecognized by health practitioners, may have devastating consequences. The pattern of hepatotoxicity observed during therapy with the vasodilator hydralazine is highly variable, often making its diagnosis difficult. Serious hepatic injury induced by the α‐ and β‐adrenergic receptor antagonist labetalol has only recently been reported and therefore, many clinicians may be unaware of this adverse effect. Familiarity with the clinical features and course of hydralazine‐ and labetalol‐induced hepatic injury is necessary to ensure prompt recognition and discontinuation of the agent.