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Diagnosis and Treatment of Skin and Soft Tissue Infections: Clinical Experience with Ticarcillin Disodium‐Clavulanate Potassium
Author(s) -
Pankey George A.
Publication year - 1991
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1991.tb02625.x
Subject(s) - medicine , soft tissue , debridement (dental) , skin infection , ticarcillin , antibiotics , incision and drainage , dermatology , intensive care medicine , surgery , staphylococcus aureus , abscess , microbiology and biotechnology , bacteria , amoxicillin , clavulanic acid , biology , genetics
The skin has highly effective mechanical, chemical, and immunologic defenses against microbial invasion. These defenses can be breached, however, when the surface of the skin is broken or when hematologic spread of infection reaches the skin or its underlying tissues. Host factors such as diabetes mellitus may also predispose individuals to skin and soft tissue infections, some of which may threaten limb or life. Management of serious infections of the skin and soft tissue often requires thorough drainage and surgical debridement, as well as aggressive antibiotic therapy. Empiric antibiotic therapy of life‐threatening skin structure infections should use an agent effective against a broad range of gram‐positive and gram‐negative, aerobic, and anaerobic organisms, including producers of ß‐lactamase enzymes. The combination of ticarcillin disodium and clavulanate potassium is such an agent, and is safe and effective in the treatment of serious skin and soft tissue infections.