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Monotherapy versus Combination Antimicrobial Therapy: A Review
Author(s) -
Barriere Steven L.
Publication year - 1991
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1991.tb02621.x
Subject(s) - antimicrobial , combination therapy , medicine , intensive care medicine , antibiotics , antibiotic resistance , endocarditis , antibiotic therapy , microbiology and biotechnology , biology
In view of the newer antibiotics that can cover the spectrum of organisms in mixed infections, single agents are now a viable option for antimicrobial therapy. In addition, monotherapy is relatively nontoxic and possibly less costly than combination therapy. Combinations may be more effective in preventing the emergence of resistance, however, and can also provide synergistic effects. They are a necessity in mycobacterial infections, enterococcal endocarditis, and deep‐seated pseudomonal infections, as well as in patients with gram‐negative bacillary infection with profound granulocytopenia.