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Hospitalizations Because of Hypoglycemia in Users of Animal and Human Insulins. 2. Experience in the United States
Author(s) -
Jick Ms. Susan S.,
Derby Ms. Laura E.,
Gross Kenneth M.,
Jick Hershel
Publication year - 1990
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1990.tb03570.x
Subject(s) - hypoglycemia , medicine , confidence interval , population , insulin , pediatrics , endocrinology , intensive care medicine , environmental health
In a 10‐year (1979–1988) follow‐up study of young insulin‐dependent diabetics carried out at Group Health Cooperative of Puget Sound, the frequency of hospitalization for hypoglycemia remained constant. During the early years only animal insulins were available; during the latter years, human insulins were used in a majority of patients. The adjusted relative risk estimate for hospitalizations for hypoglycemia comparing users of human with users of animal insulins was 0.6 (95% confidence interval 0.2, 2.3). We conclude that the use of human insulins is not associated with an increased risk of hospitalization for hypoglycemia as compared with animal insulins in this population.