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Hemodialysis Removal of Propafenone
Author(s) -
Burgess Ellen D.,
Duff Henry J.
Publication year - 1989
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1989.tb04145.x
Subject(s) - hemodialysis , dosing , medicine , bioavailability , propafenone , pharmacokinetics , end stage renal disease , anesthesia , urology , surgery , pharmacology , atrial fibrillation
Propafenone kinetics were studied after intravenous and oral dosing in a patient with end‐stage renal disease. Hemodialysis was performed within 10 hours of dosing in order to assess its effects. After intravenous administration of 70 mg propafenone, total‐body clearance was 10.5 ml/min/kg before and 10.4 ml/min/kg during hemodialysis. After a single oral dose of 300 mg, clearance was 19.4 ml/min/kg before and 18.9 ml/min/kg during hemodialysis. Bioavailability was 48%.