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Effect of Metoclopramide, Bethanechol, and Loperamide on Gastric Residence Time, Gastric Emptying, and Mouth‐to‐Cecum Transit Time
Author(s) -
Kirby M. Gray,
Dukes George E.,
Heizer William D.,
Bryson Judy C.,
Powell J. Robert
Publication year - 1989
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1989.tb04130.x
Subject(s) - bethanechol , metoclopramide , gastric emptying , loperamide , cecum , medicine , antiemetic , gastroenterology , anesthesia , stomach , diarrhea , vomiting , receptor , muscarinic acetylcholine receptor
The effects of metoclopramide, bethanechol, and loperamide on the gastric residence time (GRT), gastric emptying (GE), and mouth‐to‐cecum transit time (MCTT) of a solution were investigated in three separate studies of five healthy male volunteers each. Metoclopramide in doses of 5, 10, and 15 mg prolonged GRT by 33, 88, and 162%, respectively, almost reaching statistical significance (p 0.058). A relationship was observed between GRT prolongation, and metoclopramide area under the plasma‐time curve (p 0.01) and metoclopramide observed time to maximum concentration (p 0.01). Metoclopramide had an inconsistent effect on MCTT. Bethanechol 50 mg prolonged GRT by 64% (p 0.031) and had no effect on MCTT. Loperamide at doses of 2 and 8 mg prolonged GRT by 18 and 115% (p 0.043) and MCTT by 30 and 130% (p 0.0001), respectively. None of these motility‐altering agents affected GE.