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The 4‐Quinolone Antibiotics: Past, Present, and Future
Author(s) -
Stein Gary E.
Publication year - 1988
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1988.tb04088.x
Subject(s) - quinolone , antibiotics , antimicrobial , cephalosporin , broad spectrum , parallels , medicine , chemistry , biology , microbiology and biotechnology , combinatorial chemistry , engineering , operations management
During the past 5 years the 4‐quinolone antibiotics have progressed from relative obscurity to a highly visible and intensely studied class of compounds. The zeal for developing and marketing newer fluoroquinolones closely parallels that of the cephalosporins for the last 10 years. All of these newer agents appear to have similar mechanisms of action, but numerous derivatives of the basic 4‐quinolone structure have been synthesized in an effort to enhance the antimicrobial spectrum and pharmacologic properties of these antibiotics.