Premium
DDAVP in the Treatment of Bleeding Disorders
Author(s) -
Salva Kathryn M.,
Kim Hugh C.,
Nahum Kenneth,
Fallot Paul L.
Publication year - 1988
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1988.tb03542.x
Subject(s) - vasopressin , hemostasis , von willebrand factor , medicine , clotting factor , von willebrand disease , arginine , coagulopathy , human immunodeficiency virus (hiv) , immunology , gastroenterology , platelet , biology , biochemistry , amino acid
Hemophilia A and von Willebrand's disease are hereditary disorders associated with qualitative and quantitative abnormalities of clotting factor VIII. A major clinical feature is excessive or abnormal bleeding often necessitating the use of transfusions of pooled blood products to achieve hemostasis. Exposure to blood products places the recipient at risk for infection by the hepatitis B virus or the human immunodeficiency virus. A synthetic analog of arginine vasopressin, 1‐desamino‐8‐d‐arginine vasopressin, has been shown to increase the plasma levels of factor VIII coagulant activity and von Willebrand's factor, and clinically to improve abnormal bleeding, obviating the need to use blood products.