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Ganciclovir Hepatotoxicity
Author(s) -
Shea Brian F.,
Hoffman Stephen,
Sesin G. Paul,
Hammer Scott M.
Publication year - 1987
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1987.tb03529.x
Subject(s) - ganciclovir , medicine , toxicity , liver function tests , gastroenterology , liver function , alkaline phosphatase , drug , toxic hepatitis , liver toxicity , retinitis , hepatic function , cytomegalovirus , human cytomegalovirus , immunology , pharmacology , herpesviridae , viral disease , hepatitis , human immunodeficiency virus (hiv) , virus , enzyme , biochemistry , chemistry
A 33‐year‐old male with acquired immunodeficiency syndrome received ganciclovir for presumed cytomegalovirus retinitis. Although results of baseline liver function tests were abnormal, marked elevations of transaminases and alkaline phosphatase occurred when the drug was first instituted, as well as after rechallenge. These elevated laboratory values declined on each occasion that the drug was withdrawn. As no other toxic or infectious insults could clearly be incriminated in these acute, self‐limited episodes of hepatic function abnormalities, ganciclovir was most likely responsible for the toxicity observed in this patient.