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Excretion of Flurbiprofen into Breast Milk
Author(s) -
Cox Steven R.,
Forbes Kristi K.
Publication year - 1987
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1987.tb03527.x
Subject(s) - flurbiprofen , breast milk , chemistry , excretion , breast feeding , medicine , endocrinology , pharmacology , biochemistry , pediatrics
The extent of flurbiprofen's excretion into mature (postcolostrum) breast milk was evaluated in 10 healthy, nursing mothers after administration of a single 100‐mg tablet. Samples of milk and blood were subsequently obtained over a 48‐hour period and assayed for flurbiprofen by high‐performance liquid chromatography. The average peak plasma flurbiprofen concentration, 15 μg/ml, occurred at 1.5 hours, and the harmonic mean half‐life of the drug was 5.8 hours. The average peak milk concentration of flurbiprofen was 0.09 μg/ml, and the maximum recovery of the dose in breast milk was only 0.07%.