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Potential Therapeutic Indications for Growth Hormone and Growth Hormone‐releasing Hormone in Conditions other than Growth Retardation
Author(s) -
Williams Timothy C.,
Frohman Lawrence A.
Publication year - 1986
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1986.tb03493.x
Subject(s) - growth hormone , hormone , recombinant dna , endocrinology , medicine , bovine somatotropin , human growth hormone , growth hormone deficiency , growth hormone–releasing hormone , biology , biochemistry , gene
Growth hormone (GH) previously was available in limited supply and only for the treatment of GH‐deficient children. The recent production of GH by recombinant DNA technology has provided a potential surfeit of this hormone and raises the possibility of its use in other conditions. In addition, the isolation, characterization, and synthesis of GH‐releasing hormone (GRH) provides an opportunity to use this peptide in conditions in which increased circulating levels of GH are desired. Both GH and GRH have potential therapeutic uses in conditions other than growth retardation.