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A Double‐blind Study Comparing Single Dose of Intramuscularly Injected Zomepirac to Meperidine in the Treatment of Postoperative Pain
Author(s) -
Baird Walter M.,
Turek M. DiAnn,
Minn Fredrick L.,
Brown Robert H.
Publication year - 1986
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1986.tb03480.x
Subject(s) - medicine , pethidine , anesthesia , analgesic , double blind , adverse effect , surgery , alternative medicine , pathology , placebo
Eighty‐eight patients with moderate or severe postoperative pain were entered into a double‐blind, single‐injection trial designed to assess the analgesic efficacy of intramuscular zomepirac 100 mg. Patients were randomly selected to receive zomepirac injection, meperidine 100 mg or meperidine 50 mg. By most criteria of analgesic efficacy, zomepirac was superior to meperidine 50 mg and as effective as meperidine 100 mg. In terms of peak analgesia (and of patients' global evaluations), both meperidine 100 mg and zomepirac were superior to meperidine 50 mg. Total analgesia provided by zomepirac was greater than that with meperidine 100 mg, which was greater than that with meperidine 50 mg. Significantly fewer patients needed remedication during the observation period, and mean time to remedication was significantly longer for the zomepirac group than for either meperidine group. No serious adverse effects were reported.