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Neuroleptic‐induced Catatonia After Abrupt Withdrawal of Amantadine During Neuroleptic Therapy
Author(s) -
Brown Candace S.,
Wittkowsky Ann K.,
Bryant Stephen G.
Publication year - 1986
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1986.tb03475.x
Subject(s) - amantadine , catatonia , medicine , discontinuation , neuroleptic malignant syndrome , dopaminergic , anesthesia , blockade , pharmacology , dopamine , psychiatry , schizophrenia (object oriented programming) , receptor
Catatonic reactions to high‐potency neuroleptic drugs have been described in the literature. Our patient developed neuroleptic‐induced catatonia (NIC) after abrupt withdrawal of amantadine, a dopaminergic agent that has been implicated in neuroleptic malignant syndrome (NMS) on its discontinuation. This case report adds support to the hypothesis that NIC and NMS are 2 syndromes on a continuum of dopamine blockade, each of which may be treated with or uncovered by amantadine therapy.