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Evaluation of the Pharmacodynamic and Pharmacokinetic Interaction Between Calcium Antagonists and Digoxin
Author(s) -
Vito Joseph M.,
Friedman Basil
Publication year - 1986
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1986.tb03456.x
Subject(s) - digoxin , pharmacodynamics , medicine , antagonist , heart failure , pharmacokinetics , calcium , pharmacology , drug interaction , receptor
Therapeutic uses of calcium antagonists have expanded to include not only ischemic heart disease but arrhythmias, systemic hypertension, congestive heart failure, and various pulmonary and gastrointestinal diseases. Many patients receiving a calcium antagonist concomitantly receive digoxin. Although the potential interaction between these agents has frequently been investigated, literature reports are confusing and inconsistent. We summarized the pharmacodynamics, pharmacokinetics, and mechanisms of interaction to help clinicians evaluate the potential calcium antagonist‐digoxin interaction.